EBV genes and B cell proliferation.

2. EBV genes required for B cell proliferation in vitro . . . . . . . . . . . . . . . . . . . . . . . . 131 2.1. EBNA2 and EBNA-LP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131 2.1.1. Co-operation in cell cycle progression . . . . . . . . . . . . . . . . . . . . . . . . 131 2.1.2. Co-operation in transcriptional activation . . . . . . . . . . . . . . . . . . . . . . 131 2.2. EBNA3A and EBNA3C. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132 2.2.1. EBNA3A, EBNA3B and EBNA3C represses EBNA2-mediated transcriptional activation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 2.2.2. EBNA3A is essential for initiation of B cell immortalisation . . . . . . . . . . . 133 2.2.3. EBNA3C as an oncoprotein co-operating with ras . . . . . . . . . . . . . . . . . 133 2.3. LMP1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 134 2.3.1. LMP1 acts as a constitutively activated membrane receptor . . . . . . . . . . . . 135 2.3.2. LMP1 induces NF-kB and AP-1 activity. . . . . . . . . . . . . . . . . . . . . . . 135